{Jian Zheng Xinye Ni Zeyi Li Gang Yuan Ziyu Wang Weiwei Cao Yuzhu Cao}

Abstract

The performance and speed of medical image registration have been greatly boosted by advanced deep-learning based methods. However, most current methods are challenged by large deformations between input images, which necessitate a compromise in computational cost to enhance the model’s receptive field and its ability to model long-range spatial relationships for improving registration performance. In order to enhance the performance of registration for images with large deformations at a lower computational cost, in this paper, we propose a light-weight registration model with the ability to model large receptive fields and long-range spatial relationships, named LL-Net. The core components of LL-Net consist of a Rectangular Decomposition Large Kernel Attention (RD-LKA) layer and a Spatial and Channel Fusion Attention (SC-Fusion) layer. The RD-LKA layer utilizes anisotropic depth-wise large kernel convolutions to capture large receptive fields with an extremely low parameter count while modeling long-range spatial relationships. Moreover, the SC-Fusion layer enhances the model’s feature fusion capability and strengthens feature representations at critical locations. Our LL-Net exhibits state-of-the-art performance across multiple datasets. Specifically, it achieves a Dice score of 76.7% and an HD95 of 2.983 mm on the IXI dataset, and a Dice score of 87.8% and an HD95 of 1.042 mm on the OASIS dataset. Experimental results substantiate the efficacy of LL-Net in capturing large receptive fields and modeling long-range spatial relationships. The code for LL-Net is available at https://github.com/BoyOfChu/LL_Net.